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Interferon-alpha inhibits proliferation and induces apoptosis of merkel cell carcinoma in vitro.
Krasagakis, Konstantin; Krüger-Krasagakis, Sabine; Tzanakakis, George N; Darivianaki, Katherine; Stathopoulos, Efstathios N; Tosca, Androniki D.
Affiliation
  • Krasagakis K; Department of Dermatology, Faculty of Medicine, University of Crete, Heraklion, Greece. krasagak@med.uoc.gr
Cancer Invest ; 26(6): 562-8, 2008 Jul.
Article in En | MEDLINE | ID: mdl-18584346
Merkel cell carcinoma is a tumor with aggressive biological behavior and limited response to chemotherapy. The present study investigated the effect of interferon (IFN)-alpha on growth and apoptosis of Merkel carcinoma cells in vitro. Proliferation of MCC-1 cell line was reduced dose-dependently by IFN-alpha and diminished when higher IFN-alpha concentrations were used. Additionally, IFN-alpha potently decreased DNA-synthesis and Ki67/MIB-1 proliferation index of MCC-1 cultures. Furthermore, IFN-alpha induced dose-dependently apoptosis of MCC-1 cells as shown by caspase-3 activation, and detection of apoptotic DNA strand breaks and fragmented nuclei. These findings suggest that IFN-alpha may have antitumor activity against Merkel cell carcinoma.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Carcinoma, Merkel Cell / Interferon-alpha / Apoptosis / Merkel Cells / Cell Proliferation / Antineoplastic Agents Limits: Humans Language: En Journal: Cancer Invest Year: 2008 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Carcinoma, Merkel Cell / Interferon-alpha / Apoptosis / Merkel Cells / Cell Proliferation / Antineoplastic Agents Limits: Humans Language: En Journal: Cancer Invest Year: 2008 Document type: Article Affiliation country: Country of publication: