Interferon-alpha inhibits proliferation and induces apoptosis of merkel cell carcinoma in vitro.
Cancer Invest
; 26(6): 562-8, 2008 Jul.
Article
in En
| MEDLINE
| ID: mdl-18584346
Merkel cell carcinoma is a tumor with aggressive biological behavior and limited response to chemotherapy. The present study investigated the effect of interferon (IFN)-alpha on growth and apoptosis of Merkel carcinoma cells in vitro. Proliferation of MCC-1 cell line was reduced dose-dependently by IFN-alpha and diminished when higher IFN-alpha concentrations were used. Additionally, IFN-alpha potently decreased DNA-synthesis and Ki67/MIB-1 proliferation index of MCC-1 cultures. Furthermore, IFN-alpha induced dose-dependently apoptosis of MCC-1 cells as shown by caspase-3 activation, and detection of apoptotic DNA strand breaks and fragmented nuclei. These findings suggest that IFN-alpha may have antitumor activity against Merkel cell carcinoma.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Neoplasms
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Carcinoma, Merkel Cell
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Interferon-alpha
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Apoptosis
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Merkel Cells
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Cell Proliferation
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Cancer Invest
Year:
2008
Document type:
Article
Affiliation country:
Country of publication: